PI: Jonathan Ling (Pathology)

Co-I: Benjamin Langmead (Computer Science)

Transactive response DNA-binding protein 43kDa (TDP-43) is an RNA-binding protein known to form pathological inclusions in a variety of age-related neurodegenerative disorders. This proposal aims to mine the vast public RNA sequencing archives to uncover new mechanisms of TDP-43 dysregulation. Using an interdisciplinary approach, these findings will be validated with in silico and in vitro model systems. Insights gained from this study may reveal novel therapeutic targets and prophylactic measures to reduce the aggregation of TDP-43 and other misfolded proteins during aging.