Hong Kai Ji (Biostatistics)

Ted Dawson (Neurology (SOM),Neurology (JHH), Neuroscience (SOM))

Valina Dawson (Neurology (SOM), Neuroscience (SOM), Physiology (SOM))

In this project the investigators will develop a data science approach for studying global gene regulation. They will utilize massive amounts of publicly available functional genomic data to build computational models to predict genome-wide cis-regulatory element activities based on gene expression data. The investigators will develop new high-dimensional regression and prediction methods for big data and test the feasibility of predicting cis-regulatory element activities in samples where the available material is insufficient for conventional ChIP-seq and DNase-seq experiments.